ORM1 MEDIATES OSTEOBLAST/OSTEOCLAST CROSSTALK IN ADOLESCENT IDIOPATHIC SCOLIOSIS VIA RANKL/OPG RATIO ALTERATION

ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration

Adolescent idiopathic scoliosis (AIS), a complex early-onset three-dimensional spinal deformity, remains etiologically ambiguous despite extensive ongoing investigations.Currently, braces and surgeries are primary treatments of AIS, which come with inherent risks and costs.Therefore, there is an urgent need for biotherapeutic targets for AIS.Using

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Observational therapeutics: Scope, challenges, and organization

The importance of Observational Therapeutics in the progress of medicine has been neglected in the current era of the hierarchal position imparted to Randomized Controlled Trials (RCTs) for new drug Velvet Bar Chair discovery and practice of evidence-based medicine.There is a need to reflect on the reason for many new drugs being withdrawn during p

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The Loneliness of the self and the Moral immanent in Albert Camus

The world, the way we grasp, is not understandable and we do not know how the world will come to 6 an end or what comes after.The present article analyses critically a moral based upon immanence only when man find out that the self is alone and the other is an outsider according to French Philosopher Albert Camus.God keeps far and speechless and hu

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Chiral phonon induced spin polarization

The current understanding of chirality suggests the existence of a connection between structure and angular momentum, including spin.This is particularly emphasized in the chiral induced spin selectivity effect, where chiral structures act as spin filters.However, the recent discovery of chiral phonons have demonstrated that phonons too may carry E

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